--- title: "VIP | PepTracker Pro" description: "A neuropeptide with broad neuroimmune functions, studied for inflammatory conditions and nerve repair." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "Organization", "name": "PepTracker Pro", "url": "https://peptrackerpro.com", "logo": "https://peptrackerpro.com/favicon.png", "description": "Evidence-based educational resource dedicated to improving peptide research literacy.", "contactPoint": { "@type": "ContactPoint", "email": "hello@peptrackerpro.com", "contactType": "customer support" }, "sameAs": [] }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "VIP", "description": "A neuropeptide with broad neuroimmune functions, studied for inflammatory conditions and nerve repair.", "url": "https://peptrackerpro.com/peptides/vip", "lastReviewed": "2026-07-01", "reviewedBy": { "@type": "Organization", "name": "PepTracker Pro Research Team", "url": "https://peptrackerpro.com" }, "isPartOf": { "@type": "WebSite", "name": "PepTracker Pro", "url": "https://peptrackerpro.com" } }, { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://peptrackerpro.com" }, { "@type": "ListItem", "position": 2, "name": "Peptides", "item": "https://peptrackerpro.com/peptides" }, { "@type": "ListItem", "position": 3, "name": "VIP", "item": "https://peptrackerpro.com/peptides/vip" } ] }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "People researching CIRS treatment protocols?", "acceptedAnswer": { "@type": "Answer", "text": "VIP is a research peptide studied in preclinical models. A neuropeptide with broad neuroimmune functions, studied for inflammatory conditions and nerve repair." } }, { "@type": "Question", "name": "Those interested in neuroimmune peptides?", "acceptedAnswer": { "@type": "Answer", "text": "VIP is a research peptide studied in preclinical models. A neuropeptide with broad neuroimmune functions, studied for inflammatory conditions and nerve repair." } }, { "@type": "Question", "name": "Individuals exploring neuroprotective approaches?", "acceptedAnswer": { "@type": "Answer", "text": "VIP is a research peptide studied in preclinical models. A neuropeptide with broad neuroimmune functions, studied for inflammatory conditions and nerve repair." } } ] } ] --- [Skip to main content](#main) **Educational information only.** This site does not provide medical advice. [Read full disclaimer](/disclaimer) [PepTracker Pro](/) [Home](/)[Peptides](/peptides)[Compare](/compare)[Glossary](/glossary)[Blog](/blog)[Calculators](/calculators)[Start Here](/start) [Open the App](https://app.peptrackerpro.com) [Peptides](/peptides)/ VIP **Research-only content.** This page is for educational purposes and does not constitute medical advice. [Read full disclaimer →](/research-disclaimer) # VIP Medium Evidence A neuropeptide with broad neuroimmune functions, studied for inflammatory conditions and nerve repair. Aliases Vasoactive Intestinal Peptide Evidence Medium Evidence Last Updated 2026-07-01 Reading Time 2 min ## Table of Contents 1. [What It Is](#what-it-is) 2. [Why Researchers Study It](#why-researchers-study) 3. [Proposed Mechanisms](#proposed-mechanisms) 4. [Evidence Snapshot](#evidence-snapshot) 5. [Commonly Discussed Benefits](#benefits) 6. [Safety & Cautions](#safety) 7. [Comparisons](#comparisons) 8. [Calculator Tools](#calculator) 9. [Citations](#citations) ## What It Is Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide widely distributed throughout the central and peripheral nervous systems, gastrointestinal tract, and immune system. It functions as a neurotransmitter, neuromodulator, and potent vasodilator with broad anti-inflammatory and immunoregulatory properties. VIP signals through VPAC1 and VPAC2 receptors, which are coupled to adenylyl cyclase and activate the cAMP/PKA signaling cascade. In the lungs, VIP acts as a bronchodilator and pulmonary vasodilator, and VIP deficiency has been documented in patients with pulmonary arterial hypertension (PAH). Inhaled VIP has been studied in small clinical trials for PAH and showed improvements in pulmonary hemodynamics and exercise capacity. VIP's immunomodulatory effects are particularly notable — it suppresses pro-inflammatory cytokine production (TNF-α, IL-6, IL-12) while promoting regulatory T-cell differentiation, making it a candidate for autoimmune and inflammatory conditions. Research published in 2024–2025 has expanded investigation into VIP's neuroprotective effects, including its potential role in Parkinson's disease and neuroinflammation. VIP has a very short plasma half-life (approximately 1 minute), which limits its therapeutic utility without specialized delivery systems. It was returned to Category 1 compounding eligibility under the FDA's 2026 reclassification and is not FDA-approved as a drug product. Also known as: Vasoactive Intestinal Peptide ## Why Researchers Study It VIP is studied for its unique combination of vasodilatory, anti-inflammatory, and neuroprotective properties mediated through the VPAC receptor system. Its documented deficiency in pulmonary hypertension patients and its broad immunomodulatory effects make it relevant to multiple therapeutic areas. The challenge of its extremely short half-life has driven research into depot formulations, liposomal delivery, and longer-acting VIP analogs. ## Proposed Mechanisms - Binds PAC1 and VPAC receptors on immune cells and neurons - Suppresses pro-inflammatory Th1/Th17 responses while preserving Treg function - Restores normal circadian-immune coupling through VIP/PACAP signaling - Modulates vagal tone and parasympathetic anti-inflammatory pathways - Promotes angiogenesis and vasodilation via VIP receptor signaling ## Evidence Snapshot Medium Evidence Low Medium High ## Commonly Discussed Benefits [Nerve Repair](/benefits/nerve-repair)[Inflammation](/benefits/inflammation)[Immune Support](/benefits/immune-support)[Neuroprotection](/benefits/neuroprotection) Researching VIP ? Track it, set reminders, and keep notes in the free app. [Track in App](https://app.peptrackerpro.com/?add=vip) ## Safety & Cautions - Clinical use still investigational for most conditions - May cause vasodilation and blood pressure changes - Requires specific delivery methods (nasal, injection) - Not FDA-approved as a standalone therapeutic ## Comparisons See how VIP compares to related peptides: [VIP vs Ara-290](/compare/vip-vs-ara-290) [VIP vs Cerebrolysin](/compare/vip-vs-cerebrolysin) [VIP vs Davunetide](/compare/vip-vs-davunetide) [VIP vs Efzofitimod](/compare/vip-vs-efzofitimod) [VIP vs Selank](/compare/vip-vs-selank) ## Calculator Tools Use our research tools to explore dosing and reconstitution data: [Reconstitution Calculator](/calculators) ## Citations 1. \[1\] Delgado M. et al. — Vasoactive intestinal peptide: a neuropeptide with immunomodulatory function. Ann N Y Acad Sci. 2004 [PubMed](https://pubmed.ncbi.nlm.nih.gov/) ### Keep researching in the app - Log VIP to your private tracker - Set a dosing reminder - Compare it side-by-side with your stack [Open PepTracker Pro Free](https://app.peptrackerpro.com/?add=vip) [Browse more peptides](/peptides) ## Related Peptides ### Ara-290 Medium Evidence A non-erythropoietic EPO analog studied for nerve repair and neuropathic pain conditions. [Nerve Repair](/benefits/nerve-repair)[Pain Relief](/benefits/pain-relief)[Inflammation](/benefits/inflammation)[Recovery](/benefits/recovery) [View Details](/peptides/ara-290) [\+ Compare](/compare?select=ara-290)[](https://app.peptrackerpro.com/?add=ara-290) ### Cerebrolysin Medium Evidence A porcine brain-derived peptide mixture approved in some countries for stroke recovery and neurodegenerative conditions. [Neuroprotection](/benefits/neuroprotection)[Cognition](/benefits/cognition)[Recovery](/benefits/recovery) [View Details](/peptides/cerebrolysin) [\+ Compare](/compare?select=cerebrolysin)[](https://app.peptrackerpro.com/?add=cerebrolysin) ### Davunetide Low Evidence An eight-amino-acid ADNP-derived peptide studied for microtubule stabilization, tau-related neuroprotection, and rare ADNP syndrome. [Cognition](/benefits/cognition)[Neuroprotection](/benefits/neuroprotection) [View Details](/peptides/davunetide) [\+ Compare](/compare?select=davunetide)[](https://app.peptrackerpro.com/?add=davunetide) ### Efzofitimod Medium Evidence A first-in-class, intravenous immunomodulatory fusion peptide derived from histidyl-tRNA synthetase that selectively binds neuropilin-2 (NRP2) to dampen inflammation in the lung; in Phase 3 development for pulmonary sarcoidosis, an interstitial lung disease. [Inflammation](/benefits/inflammation)[Immune Support](/benefits/immune-support) [View Details](/peptides/efzofitimod) [\+ Compare](/compare?select=efzofitimod)[](https://app.peptrackerpro.com/?add=efzofitimod) ### Selank Medium Evidence A synthetic peptide analog of tuftsin studied for anxiolytic and nootropic properties. [Anxiety Relief](/benefits/anxiety-relief)[Mood](/benefits/mood)[Cognition](/benefits/cognition)[Neuroprotection](/benefits/neuroprotection)+1 more [View Details](/peptides/selank) [\+ Compare](/compare?select=selank)[](https://app.peptrackerpro.com/?add=selank) [PepTracker Pro](/) Educational peptide information and research tracking tools. 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