--- title: "NAD+ | PepTracker Pro" description: "A coenzyme essential for cellular energy production, studied for anti-aging and metabolic support." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "Organization", "name": "PepTracker Pro", "url": "https://peptrackerpro.com", "logo": "https://peptrackerpro.com/favicon.png", "description": "Evidence-based educational resource dedicated to improving peptide research literacy.", "contactPoint": { "@type": "ContactPoint", "email": "hello@peptrackerpro.com", "contactType": "customer support" }, "sameAs": [] }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "NAD+", "description": "A coenzyme essential for cellular energy production, studied for anti-aging and metabolic support.", "url": "https://peptrackerpro.com/peptides/nad", "lastReviewed": "2026-06-11", "reviewedBy": { "@type": "Organization", "name": "PepTracker Pro Research Team", "url": "https://peptrackerpro.com" }, "isPartOf": { "@type": "WebSite", "name": "PepTracker Pro", "url": "https://peptrackerpro.com" } }, { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://peptrackerpro.com" }, { "@type": "ListItem", "position": 2, "name": "Peptides", "item": "https://peptrackerpro.com/peptides" }, { "@type": "ListItem", "position": 3, "name": "NAD+", "item": "https://peptrackerpro.com/peptides/nad" } ] }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "People researching cellular energy and aging?", "acceptedAnswer": { "@type": "Answer", "text": "NAD+ is a research peptide studied in preclinical models. A coenzyme essential for cellular energy production, studied for anti-aging and metabolic support." } }, { "@type": "Question", "name": "Those exploring NAD+ IV therapy?", "acceptedAnswer": { "@type": "Answer", "text": "NAD+ is a research peptide studied in preclinical models. A coenzyme essential for cellular energy production, studied for anti-aging and metabolic support." } }, { "@type": "Question", "name": "Individuals comparing NAD+ precursor supplements?", "acceptedAnswer": { "@type": "Answer", "text": "NAD+ is a research peptide studied in preclinical models. A coenzyme essential for cellular energy production, studied for anti-aging and metabolic support." } } ] } ] --- [Skip to main content](#main) **Educational information only.** This site does not provide medical advice. [Read full disclaimer](/disclaimer) [PepTracker Pro](/) [Home](/)[Peptides](/peptides)[Compare](/compare)[Glossary](/glossary)[Blog](/blog)[Calculators](/calculators)[Start Here](/start) [Open the App](https://app.peptrackerpro.com) [Peptides](/peptides)/ NAD+ **Research-only content.** This page is for educational purposes and does not constitute medical advice. [Read full disclaimer →](/research-disclaimer) # NAD+ Medium Evidence A coenzyme essential for cellular energy production, studied for anti-aging and metabolic support. Aliases Nicotinamide Adenine Dinucleotide +2 more Evidence Medium Evidence Last Updated 2026-06-11 Reading Time 2 min ## Table of Contents 1. [What It Is](#what-it-is) 2. [Evidence Snapshot](#evidence-snapshot) 3. [Commonly Discussed Benefits](#benefits) 4. [Safety & Cautions](#safety) 5. [Comparisons](#comparisons) 6. [Calculator Tools](#calculator) 7. [Citations](#citations) ## What It Is NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every living cell, essential for cellular energy metabolism, DNA repair, sirtuin activation, and over 500 enzymatic reactions. While not a peptide, NAD+ is widely discussed alongside peptide protocols due to its role in metabolic optimization and its intersection with peptide targets like MOTS-c and 5-Amino-1MQ (which boosts NAD+ via NNMT inhibition). Intracellular NAD+ levels decline significantly with age — approximately 50% by middle age — and this decline is implicated in mitochondrial dysfunction, impaired DNA repair, reduced sirtuin activity, and age-related metabolic disease. NAD+ precursors (NMN, NR) and direct IV NAD+ infusion are the primary supplementation strategies. A 2024 meta-analysis of 15 randomized controlled trials found that NMN supplementation (250–1200 mg/day) consistently increased blood NAD+ metabolites, with some trials showing improvements in physical performance, insulin sensitivity, and vascular function in older adults. IV NAD+ infusions bypass first-pass metabolism and produce rapid increases in whole-blood NAD+ levels, though clinical evidence for IV routes remains limited to small, non-randomized studies. The CD38 enzyme, which degrades NAD+ and increases with aging and chronic inflammation, has emerged as a key pharmacological target. NAD+ supplementation is not FDA-approved for any medical condition but is commercially available as a dietary supplement (precursors) and through wellness clinics (IV infusions). Long-term safety data beyond 12 months remains limited. In June 2026, Noom announced that NAD+ therapies will be part of the expanded healthy-aging formulary enabled by its acquisition of 503A compounding pharmacy Tailor Made Compounding, reflecting accelerating mainstream telehealth distribution of longevity-focused compounds. Also known as: Nicotinamide Adenine Dinucleotide, NAD IV, NAD+ therapy ## Evidence Snapshot Medium Evidence Low Medium High Study Type Model Outcome Link Human (RCT, 2026) 65 healthy adults — NMN and NR at 1,000 mg/day for 14 days Doubled circulating NAD+ levels; NMN and NR performed comparably [Source](https://renuebyscience.com/pages/a-current-list-of-completed-nmn-human-trials) Human (2026) 11 healthy men — 1,200 mg/day NMN for 7 days after intense exercise Reduced inflammatory signals post-exercise [Source](https://renuebyscience.com/pages/a-current-list-of-completed-nmn-human-trials) Human (RCT) Rare diseases with premature aging and DNA damage Promising therapeutic benefits from NAD+ supplementation [Source](https://pmc.ncbi.nlm.nih.gov/articles/PMC12727671/) Human (RCT) Chronic NMN supplementation in healthy older men Elevated blood NAD+ levels; altered muscle function [Source](https://pmc.ncbi.nlm.nih.gov/articles/PMC9158788/) ## Commonly Discussed Benefits [Energy](/benefits/energy)[Longevity](/benefits/longevity)[Anti-Aging](/benefits/anti-aging)[Metabolism](/benefits/metabolism)[Neuroprotection](/benefits/neuroprotection) Researching NAD+ ? Track it, set reminders, and keep notes in the free app. [Track in App](https://app.peptrackerpro.com/?add=nad) ## Safety & Cautions - IV administration should be performed by medical professionals - Oral precursors (NMN, NR) are available as supplements but NMN's supplement status is legally contested - FDA ruled in 2022 that NMN cannot be marketed as a dietary supplement - Optimal dosing and delivery method still being studied - A 2025 lifespan study showed no difference vs placebo — anti-aging claims remain under investigation - Clinical results across studies are mixed; not all trials show meaningful benefits ## Comparisons See how NAD+ compares to related peptides: [NAD+ vs Epithalon](/compare/nad-vs-epithalon) [NAD+ vs MOTS-c](/compare/nad-vs-mots-c) [NAD+ vs SS-31](/compare/nad-vs-ss-31) ## Calculator Tools Use our research tools to explore dosing and reconstitution data: [Reconstitution Calculator](/calculators) ## Citations 1. \[1\] Rajman L. et al. — Therapeutic potential of NAD-boosting molecules. Cell Metab. 2018 [PubMed](https://pubmed.ncbi.nlm.nih.gov/29514064/) 2. \[2\] Promising Results With NAD Supplementation in Rare Diseases With Premature Aging and DNA Damage — PMC 2026 [PubMed](https://pmc.ncbi.nlm.nih.gov/articles/PMC12727671/) 3. \[3\] Updated Review on NMN and NR Mechanisms, Pre-Clinical and Clinical Comparisons — Food Frontiers. 2025 [PubMed](https://iadns.onlinelibrary.wiley.com/doi/10.1002/fft2.511) 4. \[4\] Longevity.Technology — Noom buys pharmacy to push into healthy aging [PubMed](https://longevity.technology/news/noom-buys-pharmacy-to-push-into-healthy-aging/) ### Keep researching in the app - Log NAD+ to your private tracker - Set a dosing reminder - Compare it side-by-side with your stack [Open PepTracker Pro Free](https://app.peptrackerpro.com/?add=nad) [Browse more peptides](/peptides) ## Related Peptides ### Epithalon Low Evidence A tetrapeptide studied for its potential to activate telomerase and influence biological aging markers. [Longevity](/benefits/longevity)[Anti-Aging](/benefits/anti-aging)[Sleep](/benefits/sleep)[Immune Support](/benefits/immune-support) [View Details](/peptides/epithalon) [\+ Compare](/compare?select=epithalon)[](https://app.peptrackerpro.com/?add=epithalon) ### MOTS-c Low Evidence A mitochondrial-derived peptide studied for metabolic regulation, exercise mimetic effects, and longevity. [Metabolism](/benefits/metabolism)[Fat Loss](/benefits/fat-loss)[Longevity](/benefits/longevity)[Muscle Growth](/benefits/muscle-growth)+2 more [View Details](/peptides/mots-c) [\+ Compare](/compare?select=mots-c)[](https://app.peptrackerpro.com/?add=mots-c) ### SS-31 High Evidence A mitochondria-targeted peptide FDA-approved as FORZINITY (elamipretide) for Barth syndrome in September 2025 — the first FDA-approved mitochondrial-targeted therapeutic. [Longevity](/benefits/longevity)[Anti-Aging](/benefits/anti-aging)[Recovery](/benefits/recovery)[Neuroprotection](/benefits/neuroprotection) [View Details](/peptides/ss-31) [\+ Compare](/compare?select=ss-31)[](https://app.peptrackerpro.com/?add=ss-31) [PepTracker Pro](/) Educational peptide information and research tracking tools. Not medical advice. #### Explore - [Peptide Directory](/peptides) - [Compare Peptides](/compare) - [Glossary](/glossary) - [Benefits](/benefits/sleep) #### Learn - [Blog](/blog) - [Calculators](/calculators) - [Start Here](/start) - [About](/about) #### Legal - [Editorial Policy](/editorial-policy) - [Research Disclaimer](/research-disclaimer) - [Disclaimer](/disclaimer) - [Privacy Policy](/privacy) - [Terms of Service](/terms) - [Contact](/contact) © 2026 PepTracker Pro. Educational purposes only. Not medical advice. Always consult a licensed healthcare provider.