--- title: "HMG | PepTracker Pro" description: "A gonadotropin preparation containing FSH and LH, used in fertility protocols for both men and women." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "Organization", "name": "PepTracker Pro", "url": "https://peptrackerpro.com", "logo": "https://peptrackerpro.com/favicon.png", "description": "Evidence-based educational resource dedicated to improving peptide research literacy.", "contactPoint": { "@type": "ContactPoint", "email": "hello@peptrackerpro.com", "contactType": "customer support" }, "sameAs": [] }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "HMG", "description": "A gonadotropin preparation containing FSH and LH, used in fertility protocols for both men and women.", "url": "https://peptrackerpro.com/peptides/hmg", "lastReviewed": "2026-05-27", "reviewedBy": { "@type": "Organization", "name": "PepTracker Pro Research Team", "url": "https://peptrackerpro.com" }, "isPartOf": { "@type": "WebSite", "name": "PepTracker Pro", "url": "https://peptrackerpro.com" } }, { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://peptrackerpro.com" }, { "@type": "ListItem", "position": 2, "name": "Peptides", "item": "https://peptrackerpro.com/peptides" }, { "@type": "ListItem", "position": 3, "name": "HMG", "item": "https://peptrackerpro.com/peptides/hmg" } ] }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Couples undergoing fertility treatment?", "acceptedAnswer": { "@type": "Answer", "text": "HMG is a research peptide studied in preclinical models. A gonadotropin preparation containing FSH and LH, used in fertility protocols for both men and women." } }, { "@type": "Question", "name": "Men seeking to restore spermatogenesis?", "acceptedAnswer": { "@type": "Answer", "text": "HMG is a research peptide studied in preclinical models. A gonadotropin preparation containing FSH and LH, used in fertility protocols for both men and women." } }, { "@type": "Question", "name": "Healthcare providers studying gonadotropin therapies?", "acceptedAnswer": { "@type": "Answer", "text": "HMG is a research peptide studied in preclinical models. A gonadotropin preparation containing FSH and LH, used in fertility protocols for both men and women." } } ] } ] --- [Skip to main content](#main) **Educational information only.** This site does not provide medical advice. [Read full disclaimer](/disclaimer) [PepTracker Pro](/) [Home](/)[Peptides](/peptides)[Compare](/compare)[Glossary](/glossary)[Blog](/blog)[Calculators](/calculators)[Start Here](/start) [Open the App](https://app.peptrackerpro.com) [Peptides](/peptides)/ HMG **Research-only content.** This page is for educational purposes and does not constitute medical advice. [Read full disclaimer →](/research-disclaimer) # HMG High Evidence A gonadotropin preparation containing FSH and LH, used in fertility protocols for both men and women. Aliases Human Menopausal Gonadotropin +2 more Evidence High Evidence Last Updated 2026-05-27 Reading Time 2 min ## Table of Contents 1. [What It Is](#what-it-is) 2. [Why Researchers Study It](#why-researchers-study) 3. [Proposed Mechanisms](#proposed-mechanisms) 4. [Evidence Snapshot](#evidence-snapshot) 5. [Commonly Discussed Benefits](#benefits) 6. [Safety & Cautions](#safety) 7. [Comparisons](#comparisons) 8. [Calculator Tools](#calculator) 9. [Citations](#citations) ## What It Is Human Menopausal Gonadotropin (hMG) is a purified preparation of gonadotropins extracted from the urine of postmenopausal women, containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in approximately equal proportions. It is FDA-approved under brand names including Menopur, Pergonal, and Repronex for the treatment of infertility in both women and men. In women, hMG is used for controlled ovarian hyperstimulation in assisted reproductive technology (ART) cycles to stimulate multiple follicular development. In men, hMG is used to treat hypogonadotropic hypogonadism by directly providing the FSH needed for spermatogenesis alongside LH for testosterone production. The dual FSH/LH activity of hMG distinguishes it from recombinant FSH preparations (follitropin alfa/beta), and clinical evidence suggests the LH component may improve oocyte quality and endometrial receptivity in some patient populations. A 2023 Cochrane review comparing hMG with recombinant FSH in IVF found comparable live birth rates, though hMG was associated with slightly fewer oocytes retrieved. Modern highly purified hMG preparations (hp-hMG) have improved batch-to-batch consistency compared to earlier urinary-derived products. hMG requires medical supervision and monitoring with ultrasound and estradiol levels to prevent ovarian hyperstimulation syndrome. Also known as: Human Menopausal Gonadotropin, Menopur, Repronex ## Why Researchers Study It HMG provides both FSH and LH activity in a single preparation, making it uniquely suited for protocols requiring dual gonadotropin support. In male fertility, it can simultaneously stimulate spermatogenesis (via FSH) and testosterone production (via LH), while in female reproduction it supports follicular development and ovulation. ## Proposed Mechanisms - FSH component stimulates Sertoli cells (men) and follicular growth (women) - LH component stimulates Leydig cells for testosterone production and triggers ovulation - Combined FSH/LH activity supports complete gonadal function restoration - Used in both IVF protocols and male hypogonadotropic hypogonadism treatment ## Evidence Snapshot High Evidence Low Medium High ## Commonly Discussed Benefits [Fertility](/benefits/fertility)[Hormone Support](/benefits/hormone-support) Researching HMG ? Track it, set reminders, and keep notes in the free app. [Track in App](https://app.peptrackerpro.com/?add=hmg) ## Safety & Cautions - FDA-approved for fertility treatment under medical supervision - Risk of ovarian hyperstimulation syndrome in women - Requires hormonal monitoring during use - Must be prescribed by a reproductive endocrinologist ## Comparisons See how HMG compares to related peptides: [HMG vs HCG](/compare/hmg-vs-hcg) [HMG vs Kisspeptin-10](/compare/hmg-vs-kisspeptin-10) ## Calculator Tools Use our research tools to explore dosing and reconstitution data: [Reconstitution Calculator](/calculators) ## Citations 1. \[1\] Lunenfeld B. — Historical perspectives in gonadotrophin therapy. Hum Reprod Update. 2004 [PubMed](https://pubmed.ncbi.nlm.nih.gov/) ### Keep researching in the app - Log HMG to your private tracker - Set a dosing reminder - Compare it side-by-side with your stack [Open PepTracker Pro Free](https://app.peptrackerpro.com/?add=hmg) [Browse more peptides](/peptides) ## Related Peptides ### HCG High Evidence A hormone used clinically for fertility treatment and testosterone support during hormone replacement therapy. [Hormone Support](/benefits/hormone-support)[Fertility](/benefits/fertility)[Sexual Health](/benefits/sexual-health) [View Details](/peptides/hcg) [\+ Compare](/compare?select=hcg)[](https://app.peptrackerpro.com/?add=hcg) ### Kisspeptin-10 Medium Evidence A neuropeptide that stimulates GnRH release, studied for fertility and reproductive hormone regulation. [Fertility](/benefits/fertility)[Hormone Support](/benefits/hormone-support)[Sexual Health](/benefits/sexual-health) [View Details](/peptides/kisspeptin-10) [\+ Compare](/compare?select=kisspeptin-10)[](https://app.peptrackerpro.com/?add=kisspeptin-10) [PepTracker Pro](/) Educational peptide information and research tracking tools. Not medical advice. #### Explore - [Peptide Directory](/peptides) - [Compare Peptides](/compare) - [Glossary](/glossary) - [Benefits](/benefits/sleep) #### Learn - [Blog](/blog) - [Calculators](/calculators) - [Start Here](/start) - [About](/about) #### Legal - [Editorial Policy](/editorial-policy) - [Research Disclaimer](/research-disclaimer) - [Disclaimer](/disclaimer) - [Privacy Policy](/privacy) - [Terms of Service](/terms) - [Contact](/contact) © 2026 PepTracker Pro. Educational purposes only. Not medical advice. Always consult a licensed healthcare provider.