--- title: "CJC-1295 | PepTracker Pro" description: "A growth hormone releasing hormone analog studied for stimulating growth hormone secretion." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "Organization", "name": "PepTracker Pro", "url": "https://peptrackerpro.com", "logo": "https://peptrackerpro.com/favicon.png", "description": "Evidence-based educational resource dedicated to improving peptide research literacy.", "contactPoint": { "@type": "ContactPoint", "email": "hello@peptrackerpro.com", "contactType": "customer support" }, "sameAs": [] }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "CJC-1295", "description": "A growth hormone releasing hormone analog studied for stimulating growth hormone secretion.", "url": "https://peptrackerpro.com/peptides/cjc-1295", "lastReviewed": "2026-05-27", "reviewedBy": { "@type": "Organization", "name": "PepTracker Pro Research Team", "url": "https://peptrackerpro.com" }, "isPartOf": { "@type": "WebSite", "name": "PepTracker Pro", "url": "https://peptrackerpro.com" } }, { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://peptrackerpro.com" }, { "@type": "ListItem", "position": 2, "name": "Peptides", "item": "https://peptrackerpro.com/peptides" }, { "@type": "ListItem", "position": 3, "name": "CJC-1295", "item": "https://peptrackerpro.com/peptides/cjc-1295" } ] }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "People researching growth hormone secretagogues?", "acceptedAnswer": { "@type": "Answer", "text": "CJC-1295 is a research peptide studied in preclinical models. A growth hormone releasing hormone analog studied for stimulating growth hormone secretion." } }, { "@type": "Question", "name": "Those interested in body composition research?", "acceptedAnswer": { "@type": "Answer", "text": "CJC-1295 is a research peptide studied in preclinical models. A growth hormone releasing hormone analog studied for stimulating growth hormone secretion." } }, { "@type": "Question", "name": "Individuals exploring sleep optimization?", "acceptedAnswer": { "@type": "Answer", "text": "CJC-1295 is a research peptide studied in preclinical models. A growth hormone releasing hormone analog studied for stimulating growth hormone secretion." } } ] } ] --- [Skip to main content](#main) **Educational information only.** This site does not provide medical advice. [Read full disclaimer](/disclaimer) [PepTracker Pro](/) [Home](/)[Peptides](/peptides)[Compare](/compare)[Glossary](/glossary)[Blog](/blog)[Calculators](/calculators)[Start Here](/start) [Open the App](https://app.peptrackerpro.com) [Peptides](/peptides)/ CJC-1295 **Research-only content.** This page is for educational purposes and does not constitute medical advice. [Read full disclaimer →](/research-disclaimer) # CJC-1295 Medium Evidence A growth hormone releasing hormone analog studied for stimulating growth hormone secretion. Aliases CJC-1295 DAC +2 more Evidence Medium Evidence Last Updated 2026-05-27 Reading Time 2 min ## Table of Contents 1. [What It Is](#what-it-is) 2. [Regulatory Status](#regulatory-status) 3. [Why Researchers Study It](#why-researchers-study) 4. [Proposed Mechanisms](#proposed-mechanisms) 5. [Evidence Snapshot](#evidence-snapshot) 6. [Commonly Discussed Benefits](#benefits) 7. [Safety & Cautions](#safety) 8. [Comparisons](#comparisons) 9. [Calculator Tools](#calculator) 10. [Citations](#citations) ## What It Is CJC-1295 (without DAC) is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of 29 amino acids with modified residues to improve stability and receptor binding. It stimulates the anterior pituitary to release growth hormone in a pulsatile pattern that more closely mimics natural physiology than exogenous GH administration. CJC-1295 is most commonly studied in combination with ipamorelin, where the two peptides synergistically amplify GH pulse amplitude — CJC-1295 extending the duration of the GH pulse while ipamorelin increases its peak. Clinical studies have shown that CJC-1295 increases mean plasma GH concentrations 2- to 10-fold for up to six days following a single injection, with corresponding increases in IGF-1 levels persisting for 9–11 days. The no-DAC formulation has a shorter half-life than the DAC version, which researchers often prefer for more physiological GH pulsatility rather than sustained elevation. CJC-1295 was affected by the FDA's October 2023 Category 2 designation for compounding. As of April 2026, the Category 2 nomination has been withdrawn for 503A compounding pharmacies, restoring limited compounding eligibility. It is expected to be reviewed by the PCAC before February 2027. CJC-1295 is not FDA-approved for any indication. Also known as: CJC-1295 DAC, Modified GRF 1-29, Mod GRF ## Regulatory Status Category 1 — Bulk Compounding Returned to Category 1 compounding eligibility under HHS February 27, 2026 reclassification. Legal for compounding pharmacies with a prescription. Effective: February 2026 [View FDA Source](https://www.fda.gov/drugs/human-drug-compounding/bulk-drug-substances-used-compounding) ## Why Researchers Study It CJC-1295 is of particular interest because it provides sustained growth hormone elevation through a modified GHRH structure. Its DAC variant extends the half-life to approximately one week, enabling less frequent dosing in research protocols compared to native GHRH. ## Proposed Mechanisms - Binds to GHRH receptors on anterior pituitary somatotrophs - Drug Affinity Complex (DAC) binds albumin, extending half-life to ~6–8 days - Stimulates pulsatile GH release, preserving natural secretion patterns - Increases IGF-1 levels downstream of GH elevation - Does not significantly suppress endogenous GHRH production at studied doses ## Evidence Snapshot Medium Evidence Low Medium High Study Type Model Outcome Link Human (Phase I/II) Healthy adults (n=56) 2–10 fold increase in GH levels sustained for 6+ days [Source](https://pubmed.ncbi.nlm.nih.gov/16352683/) Human (Phase I) GH-deficient adults Dose-dependent increase in IGF-1 with weekly dosing [Source](https://pubmed.ncbi.nlm.nih.gov/16352683/) ## Commonly Discussed Benefits [Muscle Growth](/benefits/muscle-growth)[Fat Loss](/benefits/fat-loss)[Recovery](/benefits/recovery)[Sleep](/benefits/sleep)[Anti-Aging](/benefits/anti-aging) Researching CJC-1295 ? Track it, set reminders, and keep notes in the free app. [Track in App](https://app.peptrackerpro.com/?add=cjc-1295) ## Safety & Cautions - May affect blood sugar levels - Potential for water retention reported in studies - Not FDA-approved for any indication - Should be discussed with a healthcare provider ## Comparisons See how CJC-1295 compares to related peptides: [CJC-1295 vs AOD-9604](/compare/cjc-1295-vs-aod-9604) [CJC-1295 vs CJC-1295 (DAC)](/compare/cjc-1295-vs-cjc-1295-dac) [CJC-1295 vs DSIP](/compare/cjc-1295-vs-dsip) [CJC-1295 vs Ipamorelin](/compare/cjc-1295-vs-ipamorelin) [CJC-1295 vs Sermorelin](/compare/cjc-1295-vs-sermorelin) [CJC-1295 vs Tesamorelin](/compare/cjc-1295-vs-tesamorelin) ## Calculator Tools Use our research tools to explore dosing and reconstitution data: [Reconstitution Calculator](/calculators) ## Citations 1. \[1\] Teichman SL. et al. — Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295. JCEM. 2006 [PubMed](https://pubmed.ncbi.nlm.nih.gov/16352683/) ### Keep researching in the app - Log CJC-1295 to your private tracker - Set a dosing reminder - Compare it side-by-side with your stack [Open PepTracker Pro Free](https://app.peptrackerpro.com/?add=cjc-1295) [Browse more peptides](/peptides) ## Related Peptides ### AOD-9604 Medium Evidence A modified fragment of human growth hormone studied for fat metabolism without growth-promoting effects. [Fat Loss](/benefits/fat-loss)[Metabolism](/benefits/metabolism)[Joint Health](/benefits/joint-health) [View Details](/peptides/aod-9604) [\+ Compare](/compare?select=aod-9604)[](https://app.peptrackerpro.com/?add=aod-9604) ### CJC-1295 (DAC) Medium Evidence A long-acting GHRH analog with an extended half-life due to its Drug Affinity Complex modification. [Muscle Growth](/benefits/muscle-growth)[Fat Loss](/benefits/fat-loss)[Recovery](/benefits/recovery)[Sleep](/benefits/sleep)+1 more [View Details](/peptides/cjc-1295-dac) [\+ Compare](/compare?select=cjc-1295-dac)[](https://app.peptrackerpro.com/?add=cjc-1295-dac) ### DSIP Low Evidence A neuropeptide studied for its role in sleep regulation and stress modulation. [Sleep](/benefits/sleep)[Mood](/benefits/mood)[Anxiety Relief](/benefits/anxiety-relief)[Pain Relief](/benefits/pain-relief) [View Details](/peptides/dsip) [\+ Compare](/compare?select=dsip)[](https://app.peptrackerpro.com/?add=dsip) ### Ipamorelin Medium Evidence A selective growth hormone secretagogue studied for targeted GH release with fewer side effects than other GH peptides. [Muscle Growth](/benefits/muscle-growth)[Fat Loss](/benefits/fat-loss)[Recovery](/benefits/recovery)[Sleep](/benefits/sleep)+1 more [View Details](/peptides/ipamorelin) [\+ Compare](/compare?select=ipamorelin)[](https://app.peptrackerpro.com/?add=ipamorelin) ### Sermorelin Medium Evidence A GHRH analog previously FDA-approved for growth hormone deficiency diagnosis and treatment. [Muscle Growth](/benefits/muscle-growth)[Fat Loss](/benefits/fat-loss)[Sleep](/benefits/sleep)[Recovery](/benefits/recovery)+1 more [View Details](/peptides/sermorelin) [\+ Compare](/compare?select=sermorelin)[](https://app.peptrackerpro.com/?add=sermorelin) ### Tesamorelin High Evidence A GHRH analog FDA-approved for reducing visceral fat in HIV-associated lipodystrophy. [Fat Loss](/benefits/fat-loss)[Muscle Growth](/benefits/muscle-growth)[Metabolism](/benefits/metabolism)[Anti-Aging](/benefits/anti-aging) [View Details](/peptides/tesamorelin) [\+ Compare](/compare?select=tesamorelin)[](https://app.peptrackerpro.com/?add=tesamorelin) [PepTracker Pro](/) Educational peptide information and research tracking tools. Not medical advice. #### Explore - [Peptide Directory](/peptides) - [Compare Peptides](/compare) - [Glossary](/glossary) - [Benefits](/benefits/sleep) #### Learn - [Blog](/blog) - [Calculators](/calculators) - [Start Here](/start) - [About](/about) #### Legal - [Editorial Policy](/editorial-policy) - [Research Disclaimer](/research-disclaimer) - [Disclaimer](/disclaimer) - [Privacy Policy](/privacy) - [Terms of Service](/terms) - [Contact](/contact) © 2026 PepTracker Pro. Educational purposes only. Not medical advice. Always consult a licensed healthcare provider.