--- title: "Skin Peptides | PepTracker Pro" description: "Peptides explored for skin health, anti-aging, and dermatological applications." lang: en json-ld: --- [Skip to main content](#main) **Educational information only.** This site does not provide medical advice. [Read full disclaimer](/disclaimer) [PepTracker Pro](/) [Home](/)[Peptides](/peptides)[Compare](/compare)[Glossary](/glossary)[Blog](/blog)[Calculators](/calculators)[Start Here](/start) [Open the App](https://app.peptrackerpro.com) [Peptides](/peptides)/ Skin # Skin Peptides Peptides explored for skin health, anti-aging, and dermatological applications. ### Difelikefalin High Evidence Difelikefalin (Korsuva in the U.S., Kapruvia in Europe) is a synthetic tetrapeptide built entirely from D-amino acids - D-Phe-D-Phe-D-Leu-D-Lys capped with a 4-aminopiperidine-4-carboxylic acid - that acts as a selective agonist at the kappa opioid receptor. Its defining property is what it cannot do: the molecule is hydrophilic and bulky enough that it does not meaningfully cross the blood-brain barrier, so it reaches kappa receptors on peripheral sensory nerve endings, keratinocytes and immune cells while leaving the central kappa receptors that produce dysphoria and hallucinations largely untouched. It has no activity at the mu opioid receptor, so it carries neither euphoria nor respiratory depression. In the Phase 3 KALM-1 and KALM-2 trials in hemodialysis patients with moderate-to-severe chronic-kidney-disease-associated pruritus, roughly 40-51% of difelikefalin-treated patients achieved a clinically meaningful (>=3-point) reduction on the 10-point Worst Itching Intensity NRS at 12 weeks versus roughly 20-28% on placebo. The FDA approved intravenous difelikefalin in August 2021; the EU approved it as Kapruvia in April 2022. [Pain Relief](/benefits/pain-relief)[Inflammation](/benefits/inflammation)[Skin](/benefits/skin)[disease-modification](/benefits/disease-modification)+1 more [View Details](/peptides/difelikefalin) [\+ Compare](/compare?select=difelikefalin)[](https://app.peptrackerpro.com/?add=difelikefalin) ### FOXO4-DRI Low Evidence A senolytic peptide designed to selectively clear senescent cells by disrupting FOXO4-p53 interaction. [Longevity](/benefits/longevity)[Anti-Aging](/benefits/anti-aging)[Skin](/benefits/skin) [View Details](/peptides/foxo4-dri) [\+ Compare](/compare?select=foxo4-dri)[](https://app.peptrackerpro.com/?add=foxo4-dri) ### GHK-Cu High Evidence A naturally occurring copper-binding peptide studied for skin regeneration, wound healing, and anti-aging effects. [Skin](/benefits/skin)[Anti-Aging](/benefits/anti-aging)[Wound Healing](/benefits/wound-healing)[Hair Growth](/benefits/hair-growth)+2 more [View Details](/peptides/ghk-cu) [\+ Compare](/compare?select=ghk-cu)[](https://app.peptrackerpro.com/?add=ghk-cu) ### GLOW Low Evidence A multi-peptide blend of BPC-157, TB-500, and GHK-Cu formulated for tissue repair and skin rejuvenation. [Recovery](/benefits/recovery)[Wound Healing](/benefits/wound-healing)[Skin](/benefits/skin)[Anti-Aging](/benefits/anti-aging) [View Details](/peptides/glow) [\+ Compare](/compare?select=glow)[](https://app.peptrackerpro.com/?add=glow) ### Icotrokinra (ICOTYDE) High Evidence The first FDA-approved targeted oral macrocyclic peptide — an IL-23 receptor antagonist for moderate-to-severe plaque psoriasis, marking a new era for oral peptide therapeutics. [Skin](/benefits/skin)[Inflammation](/benefits/inflammation)[Immune Support](/benefits/immune-support) [View Details](/peptides/icotrokinra) [\+ Compare](/compare?select=icotrokinra)[](https://app.peptrackerpro.com/?add=icotrokinra) ### KLOW Low Evidence A multi-peptide blend combining BPC-157, TB-500, GHK-Cu, and KPV for comprehensive tissue repair and anti-inflammatory support. [Recovery](/benefits/recovery)[Wound Healing](/benefits/wound-healing)[Inflammation](/benefits/inflammation)[Skin](/benefits/skin) [View Details](/peptides/klow) [\+ Compare](/compare?select=klow)[](https://app.peptrackerpro.com/?add=klow) ### KPV Medium Evidence A tripeptide derived from alpha-MSH, studied for anti-inflammatory and gut-protective properties. [Inflammation](/benefits/inflammation)[Gut Health](/benefits/gut-health)[Skin](/benefits/skin)[Immune Support](/benefits/immune-support) [View Details](/peptides/kpv) [\+ Compare](/compare?select=kpv)[](https://app.peptrackerpro.com/?add=kpv) ### LL-37 Medium Evidence A human antimicrobial peptide studied for innate immunity, wound healing, and biofilm disruption. [Immune Support](/benefits/immune-support)[Wound Healing](/benefits/wound-healing)[Inflammation](/benefits/inflammation)[Skin](/benefits/skin) [View Details](/peptides/ll-37) [\+ Compare](/compare?select=ll-37)[](https://app.peptrackerpro.com/?add=ll-37) ### MT-1 (Melanotan I) High Evidence A melanocortin receptor agonist FDA-approved (in Europe) for preventing phototoxicity in erythropoietic protoporphyria. [Pigmentation](/benefits/pigmentation)[Skin](/benefits/skin) [View Details](/peptides/mt-1) [\+ Compare](/compare?select=mt-1)[](https://app.peptrackerpro.com/?add=mt-1) ### SNAP-8 Medium Evidence A cosmetic peptide studied for reducing the appearance of wrinkles by modulating muscle contraction signaling. [Cosmetic](/benefits/cosmetic)[Skin](/benefits/skin)[Anti-Aging](/benefits/anti-aging) [View Details](/peptides/snap-8) [\+ Compare](/compare?select=snap-8)[](https://app.peptrackerpro.com/?add=snap-8) Track Your Research with PepTracker Pro [Try the Free App →](https://app.peptrackerpro.com) [PepTracker Pro](/) Educational peptide information and research tracking tools. 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