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    Longevity Peptides

    Peptides researched in the context of aging and lifespan extension.

    Epithalon

    Low Evidence

    A tetrapeptide studied for its potential to activate telomerase and influence biological aging markers.

    FOXO4-DRI

    Low Evidence

    A senolytic peptide designed to selectively clear senescent cells by disrupting FOXO4-p53 interaction.

    Humanin

    Low Evidence

    An endogenous mitochondrial-derived peptide studied for neuroprotection, cellular stress resistance, and longevity, whose blood levels fall with age and are elevated in centenarians.

    Klotho (Alpha-Klotho)

    Low Evidence

    A naturally occurring longevity hormone (secreted alpha-klotho) being studied for cognition and brain aging; a single low-dose injection improved memory in aged monkeys, and a first-in-human Phase 1 trial in older adults is underway.

    MOTS-c

    Low Evidence

    A mitochondrial-derived peptide studied for metabolic regulation, exercise mimetic effects, and longevity.

    NAD+

    Medium Evidence

    A coenzyme essential for cellular energy production, studied for anti-aging and metabolic support.

    Pinealon

    Low Evidence

    A short bioregulatory peptide studied for neuroprotective effects and cognitive support in aging.

    SS-31

    High Evidence

    A mitochondria-targeted peptide FDA-approved as FORZINITY (elamipretide) for Barth syndrome in September 2025 — the first FDA-approved mitochondrial-targeted therapeutic.

    Thymalin

    Low Evidence

    A thymic peptide preparation studied for immune system rejuvenation and age-related immune decline.

    Thymosin Alpha-1

    High Evidence

    A thymic peptide approved in some countries for immune modulation, studied for viral infections and cancer adjunct therapy.

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